Spermine: an anti-oxidant and anti-inflammatory agent.

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Lovaas E, Carlin G

Spermine: an anti-oxidant and anti-inflammatory agent.

Free Radic Biol Med. 1991;11(5):455-61.

PubMed ID

1663062 [ View in PubMed

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Abstract

This work demonstrates that spermine is a natural antioxidant and anti-inflammatory agent. It is found that: (1) Spermine inhibits the cytochrome C reduction initiated by FMLP- or PMA-stimulated human granulocytes. (2) Spermine inhibits the Fe(III)/xanthine oxidase stimulated lipid peroxidation of brain phospholipid liposomes. The antioxidative effect disappears at high Fe(III) concentrations. (3) Spermine forms a complex with Fe(II). (4) Spermine inhibits the Fe(II)-induced depolymerization of hyaluronic acid, and EDTA abolishes this effect. (5) Spermine or spermine-Fe(II) has no superoxide mimetic effect. These findings suggest that spermine has at least two antioxidative mechanisms of action: (I) Spermine inhibits the generation of the transport of superoxide radicals from stimulated granulocytes, and (II) Spermine inhibits the Haber-Weiss reaction by forming an unreactive chelate with Fe. Spermine thus prevents generation of destructive hydroxyl radicals.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Spermine	Xanthine dehydrogenase/oxidase	Protein	Humans	Unknown	Inhibitor	Details