Amantadine increases aromatic L-amino acid decarboxylase mRNA in PC12 cells.

Article Details

Citation

Li XM, Juorio AV, Qi J, Boulton AA

Amantadine increases aromatic L-amino acid decarboxylase mRNA in PC12 cells.

J Neurosci Res. 1998 Aug 15;53(4):490-3.

PubMed ID
9710269 [ View in PubMed
]
Abstract

Amantadine is an antiviral agent that was unexpectedly found to cause symptomatic improvement in patients with Parkinsonism, although its mechanism of action remains to be elucidated. Aromatic L-amino acid decarboxylase (AADC) is a regulated enzyme that catalyzes the decarboxylation of 3,4-dihydroxyphenylalanine (L-Dopa). It may be especially important during L-Dopa therapy in Parkinsonism, during which it may be rate-limiting for the production of dopamine. This study reports the effects of amantadine on the gene expression of AADC in PC12 cells. It shows that amantadine induces AADC gene expression at concentrations of 10 and 100 microM after 24 hr of incubation. The results suggest that the stimulation of AADC mRNA by amantadine may be one of its effects on dopamine metabolism that may have relevance for potentiation of L-Dopa therapy in Parkinsonism.

DrugBank Data that Cites this Article

Drug Enzymes
DrugEnzymeKindOrganismPharmacological ActionActions
AmantadineAromatic-L-amino-acid decarboxylaseProteinHumans
Unknown
Inducer
Details