Actinomycin and DNA transcription.

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Sobell HM

Actinomycin and DNA transcription.

Proc Natl Acad Sci U S A. 1985 Aug;82(16):5328-31.

PubMed ID

2410919 [ View in PubMed

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Abstract

Recent advances in understanding how actinomycin binds to DNA have suggested its mechanism of action. Actinomycin binds to a premelted DNA conformation present within the transcriptional complex. This immobilizes the complex, interfering with the elongation of growing RNA chains. The model has a number of implications for understanding RNA synthesis.

DrugBank Data that Cites this Article

Drugs

Dactinomycin

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Dactinomycin	DNA	Nucleotide	Humans	Yes	Adduct	Details