Structure and regulation of the c-Fes protein-tyrosine kinase.
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Hellwig S, Smithgall TE
Structure and regulation of the c-Fes protein-tyrosine kinase.
Front Biosci (Landmark Ed). 2011 Jun 1;16:3146-55.
- PubMed ID
- 21622225 [ View in PubMed]
- Abstract
The c-Fes protein-tyrosine kinase is the normal cellular ortholog of several avian and feline retroviral oncoproteins. Unlike its transforming viral counterparts, c-Fes tyrosine kinase activity is tightly regulated in vivo through a mechanism involving coiled-coil oligomerization domains and other unique structural features found in its long N-terminal region. This review is focused on the regulatory features and structural biology of c-Fes, which has been implicated in normal cellular growth regulation, the innate immune response, and tumorigenesis.