PKR-dependent inflammatory signals.
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Kang R, Tang D
PKR-dependent inflammatory signals.
Sci Signal. 2012 Oct 23;5(247):pe47. doi: 10.1126/scisignal.2003511.
- PubMed ID
- 23092889 [ View in PubMed]
- Abstract
Double-stranded RNA-dependent protein kinase (PKR) is implicated in inflammation and immune dysfunction through its regulation of mitogen-activated protein kinases, interferon regulatory factor 3, nuclear factor kappaB, apoptosis, and autophagy pathways. A study shows that PKR is also required for the activation of inflammasomes and the subsequent release of high-mobility group box 1 (HMGB1) protein, a proinflammatory cytokine. Thus, the cell stress kinase PKR has multifaceted roles in the regulation of inflammatory immune responses, and PKR and HMGB1 are attractive targets for inflammasome-associated diseases.