Inhibitory profiles of captopril on matrix metalloproteinase-9 activity.

Article Details

Citation

Yamamoto D, Takai S, Miyazaki M

Inhibitory profiles of captopril on matrix metalloproteinase-9 activity.

Eur J Pharmacol. 2008 Jul 7;588(2-3):277-9. doi: 10.1016/j.ejphar.2008.04.031. Epub 2008 May 22.

PubMed ID
18501888 [ View in PubMed
]
Abstract

To investigate the inhibitory profiles of angiotensin-converting enzyme (ACE) inhibitors on matrix metalloproteinase-9 (MMP-9) activity, the inhibitory activity and molecular interaction of captopril on human MMP-9 were studied. Plasma MMP-9 and ACE activities in samples from patient with acute myocardial infarction were similarly inhibited by captopril. Molecular models showed that captopril directly bound to the MMP-9 active center. Compared with the other ACE inhibitors, the compact structure of captopril seemed to make the inhibitory profiles on the MMP-9 active site.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
CaptoprilMatrix metalloproteinase-9ProteinHumans
Unknown
Inhibitor
Details