Inhibitory profiles of captopril on matrix metalloproteinase-9 activity.
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Yamamoto D, Takai S, Miyazaki M
Inhibitory profiles of captopril on matrix metalloproteinase-9 activity.
Eur J Pharmacol. 2008 Jul 7;588(2-3):277-9. doi: 10.1016/j.ejphar.2008.04.031. Epub 2008 May 22.
- PubMed ID
- 18501888 [ View in PubMed]
- Abstract
To investigate the inhibitory profiles of angiotensin-converting enzyme (ACE) inhibitors on matrix metalloproteinase-9 (MMP-9) activity, the inhibitory activity and molecular interaction of captopril on human MMP-9 were studied. Plasma MMP-9 and ACE activities in samples from patient with acute myocardial infarction were similarly inhibited by captopril. Molecular models showed that captopril directly bound to the MMP-9 active center. Compared with the other ACE inhibitors, the compact structure of captopril seemed to make the inhibitory profiles on the MMP-9 active site.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Captopril Matrix metalloproteinase-9 Protein Humans UnknownInhibitorDetails