Effects of anti-lymphocytes and anti-thymocytes globulin on human dendritic cells.

Article Details

Citation

Monti P, Allavena P, Di Carlo V, Piemonti L

Effects of anti-lymphocytes and anti-thymocytes globulin on human dendritic cells.

Int Immunopharmacol. 2003 Feb;3(2):189-96.

PubMed ID
12586600 [ View in PubMed
]
Abstract

Dendritic cells (DC) were implicated as the mediators of primary stimulation of the immune response against donor antigen. Anti-lymphocytes globulin (ALG) and anti-thymocytes globulin (ATG) antibodies have been widely used as an immunosuppressive agent in the treatment and prevention of rejection after organ transplantation. In this study, we attempted to determine whether ATG and ALG are able to bind and interfere in human dendritic cell function. ALG and ATG bound to human DCs at least in part by recognising CD1a, MHC I, MHC II, CD11a, CD86, CD32, CD4, CD11b, CD29 and CD51/61. This binding, that was more relevant in mature DCs, induced complement-mediated lysis. ALG and ATG did not influence either the macropynocytosis of Lucifer Yellow (LY) or the receptor-mediated endocytosis of FITC-Dextran. In MLR assay, ATG and ALG were able to significantly inhibit T-cell proliferation by binding on T cell but not on dendritic cells. CONCLUSIONS: we demonstrate that ALG/ATG is able to interfere in the activation of T cells by dendritic cells in two different ways: by inhibiting the capacity of lymphocyte to proliferate after the DC stimulation and by inducing a complement-mediated lysis of DC.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Antithymocyte immunoglobulin (rabbit)Integrin alpha-LProteinHumans
Yes
Not AvailableDetails
Antithymocyte immunoglobulin (rabbit)Integrin alpha-VProteinHumans
Yes
Not AvailableDetails
Antithymocyte immunoglobulin (rabbit)Integrin beta-1ProteinHumans
Yes
Not AvailableDetails
Antithymocyte immunoglobulin (rabbit)Integrin beta-3ProteinHumans
Yes
Not AvailableDetails
Antithymocyte immunoglobulin (rabbit)Low affinity immunoglobulin gamma Fc region receptor II-bProteinHumans
Yes
Not AvailableDetails
Antithymocyte immunoglobulin (rabbit)Major histocompatibility complex class I-related gene proteinProteinHumans
Yes
Antagonist
Details
Antithymocyte immunoglobulin (rabbit)T-cell surface glycoprotein CD4ProteinHumans
Yes
Not AvailableDetails
Antithymocyte immunoglobulin (rabbit)T-lymphocyte activation antigen CD86ProteinHumans
Yes
Binder
Details