Systemic effects of topical ophthalmic beta-adrenoceptor antagonists.

Article Details

Citation

Copy to clipboard

Rait JL

Systemic effects of topical ophthalmic beta-adrenoceptor antagonists.

Aust N Z J Ophthalmol. 1999 Feb;27(1):57-64.

PubMed ID

10080340 [ View in PubMed

]

Abstract

Topical ophthalmic beta-adrenoceptor antagonists (beta-blockers) are generally recognized as the treatment of choice in glaucoma management due to favourable efficacy, safety and tolerability. Despite topical ocular administration, beta-blockers are systemically absorbed, in relatively small amounts, through the nasolacrimal drainage system and can adversely affect cardiovascular and pulmonary function. While cardioselective beta-blockers, such as betaxolol, possibly confer an advantage with respect to clinical safety through their receptor affinity, systemic effects are also influenced by other pharmacological factors, including the rate and extent of systemic absorption and the extent of plasma protein binding. These factors are reviewed to distinguish the various ophthalmic beta-blockers and to explain the observed clinical differences in the safety profiles of these medications.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Betaxolol	Beta-2 adrenergic receptor	Protein	Humans	Unknown	Antagonist	Details