LRRK2 G2019S is a common mutation in Spanish patients with late-onset Parkinson's disease.

Article Details

Citation

Infante J, Rodriguez E, Combarros O, Mateo I, Fontalba A, Pascual J, Oterino A, Polo JM, Leno C, Berciano J

LRRK2 G2019S is a common mutation in Spanish patients with late-onset Parkinson's disease.

Neurosci Lett. 2006 Mar 13;395(3):224-6. Epub 2005 Nov 18.

PubMed ID
16298482 [ View in PubMed
]
Abstract

Mutations in the leucine-rich repat kinase 2 (LRRK2) gene have been shown to cause both autosomal dominant and sporadic Parkinson's disease (PD). The common G2019S mutation shows wide geographical distribution while R1441G has been only reported in Northern Spain. The overall frequency of these mutations remains to be established. To determine the prevalence of G2019S and R1441G mutations in our population of Cantabria (Northern Spain), we recruited 105 consecutive PD patients and 310 controls and conducted genetic analysis of these mutations. G2019S was detected in eight late-onset patients (7.6%). Five of them had no relevant family history. R1441G was not detected in any of our study subjects. The prevalence of G2019S mutation in unselected late-onset PD patients might be higher than previously reported: 3/16 (18.7%) of familial PD and 5/82 (6.1%) of sporadic PD.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Leucine-rich repeat serine/threonine-protein kinase 2Q5S007Details