Investigation of binding process of chlorpromazine to bovine serum albumin by means of passive and active experiments.

Article Details

Citation

Rukhadze MD, Bezarashvili GS, Sidamonidze NS, Tsagareli SK

Investigation of binding process of chlorpromazine to bovine serum albumin by means of passive and active experiments.

Biomed Chromatogr. 2001 Oct;15(6):365-73.

PubMed ID
11559920 [ View in PubMed
]
Abstract

The association process of chlorpromazine with bovine serum albumin by both onefactoral passive and multifactoral active experiments were investigated in model systems. The dependence of absolute concentration of the free fraction of chlorpromazine on the total concentration of chlorpromazine is described by the increasing function, but the dependence of the relative concentration (free/total) on this factor is influenced by external characteristics. The concentrations of chlorpromazine, bovine serum albumin and Tritons' mixture, as principal factors of a multifactoral experiment, influence the absolute and relative values of the free fraction of chlorpromazine non-additively, ie the interaction of factors is significant.

DrugBank Data that Cites this Article

Drug Carriers
DrugCarrierKindOrganismPharmacological ActionActions
AcepromazineSerum albuminProteinHumans
Unknown
Not AvailableDetails
ChlorpromazineSerum albuminProteinHumans
Unknown
Not AvailableDetails
PipotiazineSerum albuminProteinHumans
Unknown
Not AvailableDetails
ThioproperazineSerum albuminProteinHumans
Unknown
Not AvailableDetails
ThiothixeneSerum albuminProteinHumans
Unknown
Not AvailableDetails