Aspirin and probenecid pretreatment influences the potency of thiopentone and the onset of action of midazolam.

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Dundee JW, Halliday NJ, McMurray TJ

Aspirin and probenecid pretreatment influences the potency of thiopentone and the onset of action of midazolam.

Eur J Anaesthesiol. 1986 May;3(3):247-51.

PubMed ID
3780693 [ View in PubMed
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Abstract

The effects of pretreatment with aspirin and probenecid, two drugs which are highly bound to albumin, on an induction dose of thiopentone and time to onset of action of a fixed dose of midazolam were investigated. Both drugs significantly potentiate thiopentone and shorten the induction time with midazolam. The importance of individual variations in plasma proteins in influencing the action of highly bound drugs is stressed.

DrugBank Data that Cites this Article

Drug Carriers
DrugCarrierKindOrganismPharmacological ActionActions
ProbenecidSerum albuminProteinHumans
No
Not AvailableDetails