Plasma protein binding of clonazepam in hepatic and renal insufficiency and after hemodialysis.

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Pacifici GM, Viani A, Rizzo G, Carrai M, Rane A

Plasma protein binding of clonazepam in hepatic and renal insufficiency and after hemodialysis.

Ther Drug Monit. 1987 Dec;9(4):369-73.

PubMed ID

3424402 [ View in PubMed

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Abstract

The plasma protein binding of clonazepam was investigated in healthy volunteers, cirrhotic patients, chronic uremic patients maintained on hemodialysis, and patients with reduced renal function. Each group consisted of six subjects. The unbound fraction of clonazepam (mean +/- SEM) was 13.9 +/- 0.2% in volunteers. 17.1 +/- 1.0% in cirrhotic patients, 1.56 +/- 0.5% before and 12.2 +/- 0.4% after hemodialysis in chronic uremic patients, and 16.0 +/- 0.7% in patients with poor renal function. The figure for the healthy subjects was significantly different from that of cirrhotic patients only. Binding of clonazepam to albumin and alpha 1-acid glycoprotein was also studied. Clonazepam bound preferentially to albumin.

DrugBank Data that Cites this Article

Drug Carriers

Drug	Carrier	Kind	Organism	Pharmacological Action	Actions
Clonazepam	Serum albumin	Protein	Humans	No	Not Available	Details