Effect of ascorbic acid on the binding of cloxacillin sodium to bovine serum albumin.

Article Details

Citation

Copy to clipboard

Okore VC

Effect of ascorbic acid on the binding of cloxacillin sodium to bovine serum albumin.

Arzneimittelforschung. 1994 May;44(5):671-3.

PubMed ID

8024646 [ View in PubMed

]

Abstract

Using dynamic and equilibrium dialysis methods, it has been demonstrated that ascorbic acid (CAS 50-81-7) inhibits the binding of cloxacillin sodium (CAS 7081-44-9) to bovine serum albumin (BSA) in vitro. Normally, ascorbic acid has a lower number of binding sites and a much lower binding constant for BSA than cloxacillin sodium. There is an indication that ascorbic acid inhibits the binding of cloxacillin to BSA through a noncompetitive mechanism. The probable interactions leading to the non-competitive inhibition were suggested.

DrugBank Data that Cites this Article

Drug Carriers

Drug	Carrier	Kind	Organism	Pharmacological Action	Actions
Cloxacillin	Serum albumin	Protein	Humans	No	Binder	Details