When the endogenous hallucinogenic trace amine N,N-dimethyltryptamine meets the sigma-1 receptor.
Article Details
- CitationCopy to clipboard
Su TP, Hayashi T, Vaupel DB
When the endogenous hallucinogenic trace amine N,N-dimethyltryptamine meets the sigma-1 receptor.
Sci Signal. 2009 Mar 10;2(61):pe12. doi: 10.1126/scisignal.261pe12.
- PubMed ID
- 19278957 [ View in PubMed]
- Abstract
N,N-dimethyltryptamine (DMT) is a hallucinogen found endogenously in human brain that is commonly recognized to target the 5-hydroxytryptamine 2A receptor or the trace amine-associated receptor to exert its psychedelic effect. DMT has been recently shown to bind sigma-1 receptors, which are ligand-regulated molecular chaperones whose function includes inhibiting various voltage-sensitive ion channels. Thus, it is possible that the psychedelic action of DMT might be mediated in part through sigma-1 receptors. Here, we present a hypothetical signaling scheme that might be triggered by the binding of DMT to sigma-1 receptors.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Dimethyltryptamine 5-hydroxytryptamine receptor 2A Protein Humans UnknownNot Available Details Dimethyltryptamine Sigma non-opioid intracellular receptor 1 Protein Humans UnknownNot Available Details