Receptor-mediated inotropic drugs.

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van Zwieten PA

Receptor-mediated inotropic drugs.

Eur Heart J. 1988 Jun;9 Suppl H:85-90.

PubMed ID

2901958 [ View in PubMed

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Abstract

Cardiac inotropic activity can be triggered by beta 1-, beta 2- and alpha 1-adrenoreceptors in the heart when stimulated with appropriate agonists. Dopaminergic receptor agonists have little influence on contractile force but the peripheral vasodilatation, improved renal perfusion and enhanced natriuresis mediated by dopaminergic receptor stimulation may improve a condition of congestive heart failure. After a general survey of cardiac beta- and alpha-adrenoreceptors and of dopaminergic receptors in the cardiovascular system, the following receptor-mediated inotropic drugs are discussed: isoprenaline, dobutamine, xamoterol, pirbuterol, terbutaline, salbutamol, dopamine, L-dopa and dopexamine. Attention is paid to the receptor profile of these compounds and to the scope and limitations of their application as inotropic drugs in the treatment of congestive heart failure.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Pirbuterol	Beta-1 adrenergic receptor	Protein	Humans	Unknown	Agonist	Details