Cyproheptadine displays high affinity for muscarinic receptors but does not discriminate between receptor subtypes.
Article Details
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Eltze M, Lambrecht G, Mutschler E
Cyproheptadine displays high affinity for muscarinic receptors but does not discriminate between receptor subtypes.
Eur J Pharmacol. 1989 Dec 7;173(2-3):219-22.
- PubMed ID
- 2625138 [ View in PubMed]
- Abstract
The affinity of cyproheptadine for different muscarinic receptor subtypes was investigated in vitro by functional experiments in field-stimulated vas deferens of the rabbit (ganglionic M1- and cardiac M2-receptors) and in guinea-pig ileum (smooth muscle M3-receptors). Cyproheptadine displayed high but similar affinity for all muscarinic receptor subtypes studied (pA2 = 7.99-8.02). In contrast, (+)-telenzepine (M1 over M2 and M3), and for mefurtramine (M2 over M3 and M1) were found to be selective.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Cyproheptadine Muscarinic acetylcholine receptor M1 Protein Humans UnknownAntagonistDetails Cyproheptadine Muscarinic acetylcholine receptor M2 Protein Humans UnknownAntagonistDetails Cyproheptadine Muscarinic acetylcholine receptor M3 Protein Humans UnknownAntagonistDetails