[Etravirine drug interactions].

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Perez VE, Sanchez-Parra C, Serrano Villar S

[Etravirine drug interactions].

Enferm Infecc Microbiol Clin. 2009 Dec;27 Suppl 2:27-31. doi: 10.1016/S0213-005X(09)73216-1.

PubMed ID
20116625 [ View in PubMed
]
Abstract

Etravirine (ETR) belongs to the family of non-nucleoside analogue reverse transcriptase inhibitors (NNRTIs), with antiviral activity in patients with resistance to first-generation NNRTIs. The drug interactions caused by ETR are due to its dual effect on the CYP450 system. ETR acts as an inducer of CYP3A4 and inhibitor of CYP2C9 and CYP2C19. This drug shows few clinically significant drug interactions, the most important of which involve the unboosted protease inhibitors, the NNRTIs efavirenz and nevirapine, full-dose ritonavir and tipranavir/ritonavir. Interaction with fosamprenavir/ritonavir is not clinically significant, although their plasma levels vary slightly when used in combination with ETR. ETR shows no interactions with darunavir/ritonavir.

DrugBank Data that Cites this Article

Drug Enzymes
DrugEnzymeKindOrganismPharmacological ActionActions
EtravirineCytochrome P450 2C19ProteinHumans
Unknown
Substrate
Inhibitor
Details
EtravirineCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Inhibitor
Details
EtravirineCytochrome P450 3A4ProteinHumans
Unknown
Substrate
Inducer
Details
Drug Interactions
DrugsInteraction
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interactions in your software
Etravirine
Tipranavir		The serum concentration of Etravirine can be decreased when it is combined with Tipranavir.