Interaction profile of armodafinil with medications metabolized by cytochrome P450 enzymes 1A2, 3A4 and 2C19 in healthy subjects.
Article Details
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Darwish M, Kirby M, Robertson P Jr, Hellriegel ET
Interaction profile of armodafinil with medications metabolized by cytochrome P450 enzymes 1A2, 3A4 and 2C19 in healthy subjects.
Clin Pharmacokinet. 2008;47(1):61-74.
- PubMed ID
- 18076219 [ View in PubMed]
- Abstract
BACKGROUND AND OBJECTIVE: Armodafinil, a wakefulness-promoting agent, is the pure R-enantiomer of racemic modafinil. The objective of this article is to summarize the results of three clinical drug-interaction studies assessing the potential for drug interactions of armodafinil with agents metabolized by cytochrome P450 (CYP) enzymes 1A2, 3A4 and 2C19. Study 1 evaluated the potential for armodafinil to induce the activity of CYP1A2 using oral caffeine as the probe substrate. Study 2 evaluated the potential for armodafinil to induce gastrointestinal and hepatic CYP3A4 activity using intravenous and oral midazolam as the probe substrate. Study 3 evaluated the potential for armodafinil to inhibit the activity of CYP2C19 using oral omeprazole as the probe substrate. METHODS: Healthy men and nonpregnant women aged 18-45 years with a body mass index of
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Armodafinil Cytochrome P450 2C19 Protein Humans UnknownInhibitorDetails Armodafinil Cytochrome P450 3A4 Protein Humans UnknownInducerDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareAbemaciclibModafinil The metabolism of Abemaciclib can be increased when combined with Modafinil. AbemaciclibArmodafinil The metabolism of Abemaciclib can be increased when combined with Armodafinil. AbrocitinibArmodafinil The metabolism of Abrocitinib can be decreased when combined with Armodafinil. AbrocitinibModafinil The metabolism of Abrocitinib can be decreased when combined with Modafinil. AcalabrutinibModafinil The metabolism of Acalabrutinib can be increased when combined with Modafinil.