Evidence of an interaction between nifedipine and nafcillin in humans.

Article Details

Citation Copy to clipboard

Lang CC, Jamal SK, Mohamed Z, Mustafa MR, Mustafa AM, Lee TC

Evidence of an interaction between nifedipine and nafcillin in humans.

Br J Clin Pharmacol. 2003 Jun;55(6):588-90.

PubMed ID

12814453 [ View in PubMed

]

Abstract

AIMS: Nafcillin (Wyeth Laboratories, Philadelphia, PA, USA) has been reported to induce the metabolism of cyclosporin and warfarin, which are known substrates of cytochrome P-450 (CYP). However, there has not been any report to date on its possible interaction with nifedipine, an index substrate of the enzyme, CYP3A4. METHODS: Nine healthy normotensive subjects participated in this randomized placebo-controlled two-way crossover study examining the effects of 5 days' pretreatment of nafcillin 500 mg or placebo four times daily on the pharmacokinetics of an oral dose of nifedipine 10 mg. Plasma nifedipine concentrations were measured by gas chromatography-mass spectro. RESULTS: The area under the plasma nifedipine concentration-time curve (AUC0-alpha) in nafcillin-pretreated subjects (80.9 +/- 32.9 micro g l-1 h-1) was significantly decreased compared with subjects who received only nifedipine (216.4 +/- 93.2 micro g l-1 h-1) (P < 0.001). Total plasma clearance of nifedipine (CL/F) was significantly increased with nafcillin pretreatment (138.5 +/- 42.0 l h-1 vs 56.5 +/- 32.0 l h-1) (P < 0.002). CONCLUSIONS: The results show that nafcillin pretreatment markedly increased the clearance of nifedipine and suggest that nafcillin is a potent inducer of CYP enzyme.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Nafcillin	Cytochrome P450 3A4	Protein	Humans	Unknown	Inducer	Details

Drug Interactions

Drugs	Interaction
Integrate drug-drug interactions in your software
Cyclosporine Nafcillin	The metabolism of Cyclosporine can be increased when combined with Nafcillin.