Cysteamine selectively enhances neuropeptide Y2 receptor binding activity.

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Li W, Hexum TD

Cysteamine selectively enhances neuropeptide Y2 receptor binding activity.

Biochem Biophys Res Commun. 1992 Apr 15;184(1):380-6.

PubMed ID

1314592 [ View in PubMed

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Abstract

Affinity labeling of [125I]NPY to the bovine hippocampal NPY receptor has revealed a 50 kDa specific binding protein, the Y2 receptor. Cysteamine (10 microM - 10 mM) specifically enhanced NPY specific labeling of the Y2 receptor without affecting cross-linking efficiency. Several structurally related agents, including reduced glutathione, cysteine, beta-mercaptoethanol and ethanolamine, were without effect on receptor binding. The enhancement of binding by cysteamine could be reversed by washing the membranes. These studies suggest that cysteamine may change the conformation of the NPY Y2 receptor and increase its binding activity.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Cysteamine	Neuropeptide Y receptor type 2	Protein	Humans	Unknown	Other/unknown	Details