The binding of flurbiprofen to plasma proteins.

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Aarons L, Khan AZ, Grennan DM, Alam-Siddiqi M

The binding of flurbiprofen to plasma proteins.

J Pharm Pharmacol. 1985 Sep;37(9):644-6.

PubMed ID
2867185 [ View in PubMed
]
Abstract

The binding of flurbiprofen to human serum albumin and normal plasma was measured using ultracentrifugation. Flurbiprofen was bound in excess of 99% in all cases. Over the concentration range normally associated with therapy the data could be adequately described by a one-site binding model. The association constant decreased with increasing protein concentration, being 3.04 X 10(6) M-1 at an albumin concentration, of 2 g/100 ml and 1.19 X 10(6) M-1 at a concentration of 4 g/100 ml. Flurbiprofen binding showed no dependence on pH over the range 7.0 to 8.0.

DrugBank Data that Cites this Article

Drug Carriers
DrugCarrierKindOrganismPharmacological ActionActions
FlurbiprofenSerum albuminProteinHumans
No
Other/unknown
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