cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3).

Article Details

Citation

Kiuchi Y, Suzuki H, Hirohashi T, Tyson CA, Sugiyama Y

cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3).

FEBS Lett. 1998 Aug 14;433(1-2):149-52.

PubMed ID
9738950 [ View in PubMed
]
Abstract

Previously, we cloned rat MRP3 as a candidate for an inducible transporter for the biliary excretion of organic anions [Hirohashi et al. (1998) Mol. Pharmacol. 53, 1068-10751. In the present study, we cloned human MRP3 (1527 amino acids) from Caco-2 cells. Human MRP3 is predominantly expressed in liver, small intestine and colon; hepatic expression of MRP3 was observed in humans but not in normal rats. In HepG2 cells, the expression of MRP3 was induced by phenobarbital. These results suggest that MRP3 may act as an inducible transporter in the biliary and intestinal excretion of organic anions.

DrugBank Data that Cites this Article

Drug Transporters
DrugTransporterKindOrganismPharmacological ActionActions
PhenobarbitalCanalicular multispecific organic anion transporter 2ProteinHumans
Unknown
Inducer
Details
PhenobarbitalMultidrug resistance-associated protein 1ProteinHumans
Unknown
Inducer
Details
Polypeptides
NameUniProt ID
Canalicular multispecific organic anion transporter 2O15438Details