cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3).
Article Details
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Kiuchi Y, Suzuki H, Hirohashi T, Tyson CA, Sugiyama Y
cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3).
FEBS Lett. 1998 Aug 14;433(1-2):149-52.
- PubMed ID
- 9738950 [ View in PubMed]
- Abstract
Previously, we cloned rat MRP3 as a candidate for an inducible transporter for the biliary excretion of organic anions [Hirohashi et al. (1998) Mol. Pharmacol. 53, 1068-10751. In the present study, we cloned human MRP3 (1527 amino acids) from Caco-2 cells. Human MRP3 is predominantly expressed in liver, small intestine and colon; hepatic expression of MRP3 was observed in humans but not in normal rats. In HepG2 cells, the expression of MRP3 was induced by phenobarbital. These results suggest that MRP3 may act as an inducible transporter in the biliary and intestinal excretion of organic anions.
DrugBank Data that Cites this Article
- Drug Transporters
Drug Transporter Kind Organism Pharmacological Action Actions Phenobarbital Canalicular multispecific organic anion transporter 2 Protein Humans UnknownInducerDetails Phenobarbital Multidrug resistance-associated protein 1 Protein Humans UnknownInducerDetails - Polypeptides
Name UniProt ID Canalicular multispecific organic anion transporter 2 O15438 Details