Dexamethasone modulation of multidrug transporters in normal tissues.

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Demeule M, Jodoin J, Beaulieu E, Brossard M, Beliveau R

Dexamethasone modulation of multidrug transporters in normal tissues.

FEBS Lett. 1999 Jan 15;442(2-3):208-14.

PubMed ID

9929003 [ View in PubMed

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Abstract

The expression of P-glycoprotein (P-gp) and canalicular multispecific organic anion transporter (cMOAT or Mrp2) was evaluated by Western blotting analysis of rat tissues isolated following daily administration (1 mg kg(-1) day(-1)) of dexamethasone over 4 days. Dexamethasone rapidly increased P-gp expression more than 4.5- and 2-fold in liver and lung, respectively, while it was decreased 40% in kidney. cMOAT expression was increased 2-fold in liver and kidney following dexamethasone treatment. The levels of both proteins returned to control values by 6 days after the conclusion of dexamethasone administration. These results indicate that dexamethasone can modulate P-gp and cMOAT expression in specific rat tissues and may have significant relevance for patients treated with dexamethasone as a single agent or in combination therapy with other drugs.

DrugBank Data that Cites this Article

Drug Transporters

Drug	Transporter	Kind	Organism	Pharmacological Action	Actions
Dexamethasone	Canalicular multispecific organic anion transporter 1	Protein	Humans	Unknown	Inducer	Details
Dexamethasone acetate	Canalicular multispecific organic anion transporter 1	Protein	Humans	Unknown	Inducer	Details