Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1.

Article Details

Citation

Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D, Nomura H, Unno M, Suzuki M, Naitoh T, Matsuno S, Yawo H

Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1.

J Biol Chem. 1999 Jun 11;274(24):17159-63.

PubMed ID
10358072 [ View in PubMed
]
Abstract

We have isolated a novel liver-specific organic anion transporter, LST-1, that is expressed exclusively in the human, rat, and mouse liver. LST-1 is a new gene family located between the organic anion transporter family and prostaglandin transporter. LST-1 transports taurocholate (Km = 13.6 microM) in a sodium-independent manner. LST-1 also shows broad substrate specificity. It transports conjugated steroids (dehydroepiandrosterone sulfate, estradiol-17beta-glucuronide, and estrone-3-sulfate), eicosanoids (prostaglandin E2, thromboxane B2, leukotriene C4, leukotriene E4), and thyroid hormones (thyroxine, Km = 3.0 microM and triiodothyronine, Km = 2.7 microM), reflecting hepatic multispecificity. LST-1 is probably the most important transporter in human liver for clearance of bile acids and organic anions because hepatic levels of another organic anion transporter, OATP, is very low. This is also the first report of the human molecule that transports thyroid hormones.

DrugBank Data that Cites this Article

Drug Transporters
DrugTransporterKindOrganismPharmacological ActionActions
DinoprostoneSolute carrier organic anion transporter family member 1B1ProteinHumans
Unknown
Substrate
Details
LiothyronineSolute carrier organic anion transporter family member 1B1ProteinHumans
Unknown
Substrate
Details
LiotrixSolute carrier organic anion transporter family member 1B1ProteinHumans
Unknown
Substrate
Details
Taurocholic acidSolute carrier organic anion transporter family member 1B1ProteinHumans
Unknown
Substrate
Inhibitor
Inducer
Details
Polypeptides
NameUniProt ID
Solute carrier organic anion transporter family member 1B1Q9Y6L6Details