Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2).

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Dresser MJ, Xiao G, Leabman MK, Gray AT, Giacomini KM

Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2).

Pharm Res. 2002 Aug;19(8):1244-7.

PubMed ID

12240953 [ View in PubMed

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Abstract

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DrugBank Data that Cites this Article

Drug Transporters

Drug	Transporter	Kind	Organism	Pharmacological Action	Actions
Metformin	Solute carrier family 22 member 1	Protein	Humans	Unknown	Substrate	Details
Metformin	Solute carrier family 22 member 2	Protein	Humans	Unknown	Substrate Inhibitor	Details
Phenformin	Solute carrier family 22 member 2	Protein	Humans	Unknown	Inhibitor	Details

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Metformin	Solute carrier family 22 member 1	IC 50 (nM)	2010000	N/A	N/A	Details
Metformin	Solute carrier family 22 member 2	IC 50 (nM)	1700000	N/A	N/A	Details
Phenformin	Solute carrier family 22 member 1	IC 50 (nM)	10000	N/A	N/A	Details
Phenformin	Solute carrier family 22 member 2	IC 50 (nM)	65000	N/A	N/A	Details
Tetraethylammonium	Solute carrier family 22 member 2	IC 50 (nM)	156000	N/A	N/A	Details