Current understanding of the pharmacogenomics of metformin.

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Zolk O

Current understanding of the pharmacogenomics of metformin.

Clin Pharmacol Ther. 2009 Dec;86(6):595-8. doi: 10.1038/clpt.2009.144.

PubMed ID

19915604 [ View in PubMed

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Abstract

The identification of transporters for organic cations involved in the distribution and elimination of the antidiabetic compound metformin marks a milestone in the study of metformin's pharmacokinetics. This was followed by the urgent question of whether genetic variations in these transporters can affect efficacy and risk of adverse events associated with metformin use. After a brief historical review of the discovery of the transporters for cationic drugs, the pharmacogenetics of metformin is discussed here in the light of recent literature.

DrugBank Data that Cites this Article

Drug Transporters

Drug	Transporter	Kind	Organism	Pharmacological Action	Actions
Metformin	Solute carrier family 22 member 1	Protein	Humans	Unknown	Substrate	Details
Metformin	Solute carrier family 22 member 2	Protein	Humans	Unknown	Substrate Inhibitor	Details