Two novel CTNS mutations in cystinosis patients in Thailand.
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Yeetong P, Tongkobpetch S, Kingwatanakul P, Deekajorndech T, Bernardini IM, Suphapeetiporn K, Gahl WA, Shotelersuk V
Two novel CTNS mutations in cystinosis patients in Thailand.
Gene. 2012 May 15;499(2):323-5. doi: 10.1016/j.gene.2012.03.047. Epub 2012 Mar 16.
- PubMed ID
- 22450360 [ View in PubMed]
- Abstract
Cystinosis is an autosomal recessive disorder characterized by defective transport of cystine across the lysosomal membrane and resulting in renal, ophthalmic, and other organ abnormalities. Mutations in the CTNS gene cause a deficiency of the transport protein, cystinosin. We performed mutation analysis of CTNS in six cystinosis patients from four families in Thailand. Using PCR sequencing of the entire coding regions, we identified all eight mutant alleles, including two mutations, p.G309D and p.Q284X, that have not been previously reported. This study expands the mutational and population spectrum of nephropathic cystinosis.