Protein kinase Czeta and glucose uptake.
Article Details
- CitationCopy to clipboard
Liu LZ, He AB, Liu XJ, Li Y, Chang YS, Fang FD
Protein kinase Czeta and glucose uptake.
Biochemistry (Mosc). 2006 Jul;71(7):701-6.
- PubMed ID
- 16903823 [ View in PubMed]
- Abstract
Protein kinase Czeta (PKCzeta) is a member of the PKC family, serving downstream of insulin receptor and phosphatidylinositol (PI) 3-kinase. Many evidences suggest that PKCzeta plays a very important role in activating glucose transport response. Not only insulin but also glucose and exercise can activate PKCzeta through diverse pathways. PKCzeta activation and activity are impaired with insulin resistance in muscle and adipose tissues of type II diabetes individuals, but heightened in liver tissue, wherein it also increases lipid synthesis mediated by SREBP-1c (sterol-regulatory element-binding protein). Many studies have focused on linkage between PKCzeta and GLUT4 translocation and activation. Exploring the molecular mechanisms and pathways by which PKCzeta mediates glucose transport will highlight the insulin-signaling pathway.