Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain.

Article Details

Citation

Copy to clipboard

Kullak-Ublick GA, Fisch T, Oswald M, Hagenbuch B, Meier PJ, Beuers U, Paumgartner G

Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain.

FEBS Lett. 1998 Mar 13;424(3):173-6.

PubMed ID

9539145 [ View in PubMed

]

Abstract

Dehydroepiandrosterone sulfate (DHEAS) is the major circulating steroid in man. Pharmacologically, it exerts marked neuropsychiatric effects. Since no target receptor has been identified, we investigated whether the organic anion transporting polypeptide (OATP), a multispecific steroid carrier, transports DHEAS. Expression of the human liver OATP in Xenopus laevis oocytes resulted in high-affinity, partially Na+-dependent uptake of [3H]DHEAS (Km: 6.6 micromol/l). DHEAS transport was inhibited by bromosulfophthalein, bile acids, sulfated estrogens and dexamethasone. Northern blot analysis showed widespread expression of OATP in human brain. These data identify OATP as the first known target protein of DHEAS in human liver and brain.

DrugBank Data that Cites this Article

Drug Transporters

Drug	Transporter	Kind	Organism	Pharmacological Action	Actions
Conjugated estrogens	Solute carrier organic anion transporter family member 1A2	Protein	Humans	Unknown	Substrate Inhibitor	Details
Dexamethasone	Solute carrier organic anion transporter family member 1A2	Protein	Humans	Unknown	Inhibitor	Details
Dexamethasone acetate	Solute carrier organic anion transporter family member 1A2	Protein	Humans	Unknown	Inhibitor	Details