Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.
Article Details
- CitationCopy to clipboard
Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A
Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.
Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60.
- PubMed ID
- 10873595 [ View in PubMed]
- Abstract
We identified three novel transporters structurally belonging to the organic anion transporting polypeptide (OATP) family in humans. Since previously known rat oatp1 to 3 do not necessarily correspond to the human OATPs in terms of either tissue distribution or function, here we designate the newly identified human OATPs as OATP-B, -D and -E, and we rename the previously known human OATP as OATP-A. OATP-C proved to be identical with the recently reported LST1/OATP-2. Expression profiles of the five OATPs and the prostaglandin transporter PGT (a member of OATP family) in human tissues showed that OATP-C is exclusively localized in liver, OATP-A and PGT are expressed in restricted ranges of tissues, and OATP-B, -D and -E show broad expression profiles. OATP-B, -C, -D and -E exhibited transport activity for [(3)H]estrone-3-sulfate as a common substrate. OATP-C has a high transport activity with broad substrate specificity.
DrugBank Data that Cites this Article
- Drug Transporters
- Polypeptides
Name UniProt ID Solute carrier organic anion transporter family member 2B1 O94956 Details Solute carrier organic anion transporter family member 4A1 Q96BD0 Details Solute carrier organic anion transporter family member 3A1 Q9UIG8 Details