Affinity of cefoperazone for penicillin-binding proteins.

Article Details

Citation

Matsubara N, Minami S, Matsuhashi M, Takaoka M, Mitsuhashi S

Affinity of cefoperazone for penicillin-binding proteins.

Antimicrob Agents Chemother. 1980 Jul;18(1):195-9.

PubMed ID
6448021 [ View in PubMed
]
Abstract

Cefoperazone (T-1551, CFP) a new semisynthetic cephalosporin, has a broad spectrum of antibacterial activity. We investigated the affinity of CFP to penicillin-binding proteins (PBPs) and the inhibition of peptidoglycan synthesis by CFP. CFP had high affinities for Escherichia coli PBP-3, -1Bs, -2, and -1A, in descending order, and low affinities for PBP-4, -5, and -6. Similarly, CFP showed high affinity for Pseudomonas aeruginosa PBP-3, -1A, -1B, -2, and -4, in descending order. It is known that E. coli PBP-3 and P. aeruginosa PBP-3 participate in cell division. These results are in good agreement with the formation of filamentous cells of E. coli and P. aeruginosa treated with CFP. CFP had lower inhibitory activities on D-alanine carboxypeptidase IA and IB of E. coli than that of penicillin G, but its inhibitory activities on the cross-link formation in peptidoglycan synthesis were the same as those of penicillin G and higher than those of ampicillin.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
CefoperazoneD-alanyl-D-alanine carboxypeptidase DacAProteinEscherichia coli (strain K12)
Yes
Inhibitor
Details
CefoperazoneD-alanyl-D-alanine carboxypeptidase DacBProteinEscherichia coli (strain K12)
Yes
Inhibitor
Details
CefoperazoneD-alanyl-D-alanine carboxypeptidase DacCProteinEscherichia coli (strain K12)
Yes
Inhibitor
Details
CefoperazonePenicillin-binding protein 1AProteinEscherichia coli (strain K12)
Yes
Inhibitor
Details
CefoperazonePenicillin-binding protein 1AProteinPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Yes
Inhibitor
Details
CefoperazonePenicillin-binding protein 1BProteinEscherichia coli (strain K12)
Yes
Inhibitor
Details
CefoperazonePenicillin-binding protein 1BProteinPseudomonas aeruginosa
Yes
Inhibitor
Details
CefoperazonePenicillin-binding protein 2ProteinEscherichia coli (strain K12)
Yes
Inhibitor
Details
CefoperazonePeptidoglycan synthase FtsIProteinEscherichia coli (strain K12)
Yes
Inhibitor
Details
CefpiramideD-alanyl-D-alanine carboxypeptidase DacCProteinEscherichia coli (strain K12)
Yes
Inhibitor
Details
CefpiramidePenicillin-binding protein 1AProteinPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Yes
Inhibitor
Details
CefpiramidePenicillin-binding protein 1AProteinEscherichia coli (strain K12)
Yes
Inhibitor
Details
CefpiramidePenicillin-binding protein 1BProteinEscherichia coli (strain K12)
Yes
Inhibitor
Details
CefpiramidePenicillin-binding protein 1BProteinPseudomonas aeruginosa
Yes
Inhibitor
Details
CefpiramidePeptidoglycan synthase FtsIProteinEscherichia coli (strain K12)
Yes
Inhibitor
Details