Affinity of cefoperazone for penicillin-binding proteins.
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Matsubara N, Minami S, Matsuhashi M, Takaoka M, Mitsuhashi S
Affinity of cefoperazone for penicillin-binding proteins.
Antimicrob Agents Chemother. 1980 Jul;18(1):195-9.
- PubMed ID
- 6448021 [ View in PubMed]
- Abstract
Cefoperazone (T-1551, CFP) a new semisynthetic cephalosporin, has a broad spectrum of antibacterial activity. We investigated the affinity of CFP to penicillin-binding proteins (PBPs) and the inhibition of peptidoglycan synthesis by CFP. CFP had high affinities for Escherichia coli PBP-3, -1Bs, -2, and -1A, in descending order, and low affinities for PBP-4, -5, and -6. Similarly, CFP showed high affinity for Pseudomonas aeruginosa PBP-3, -1A, -1B, -2, and -4, in descending order. It is known that E. coli PBP-3 and P. aeruginosa PBP-3 participate in cell division. These results are in good agreement with the formation of filamentous cells of E. coli and P. aeruginosa treated with CFP. CFP had lower inhibitory activities on D-alanine carboxypeptidase IA and IB of E. coli than that of penicillin G, but its inhibitory activities on the cross-link formation in peptidoglycan synthesis were the same as those of penicillin G and higher than those of ampicillin.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Cefoperazone D-alanyl-D-alanine carboxypeptidase DacA Protein Escherichia coli (strain K12) YesInhibitorDetails Cefoperazone D-alanyl-D-alanine carboxypeptidase DacB Protein Escherichia coli (strain K12) YesInhibitorDetails Cefoperazone D-alanyl-D-alanine carboxypeptidase DacC Protein Escherichia coli (strain K12) YesInhibitorDetails Cefoperazone Penicillin-binding protein 1A Protein Escherichia coli (strain K12) YesInhibitorDetails Cefoperazone Penicillin-binding protein 1A Protein Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) YesInhibitorDetails Cefoperazone Penicillin-binding protein 1B Protein Escherichia coli (strain K12) YesInhibitorDetails Cefoperazone Penicillin-binding protein 1B Protein Pseudomonas aeruginosa YesInhibitorDetails Cefoperazone Penicillin-binding protein 2 Protein Escherichia coli (strain K12) YesInhibitorDetails Cefoperazone Peptidoglycan synthase FtsI Protein Escherichia coli (strain K12) YesInhibitorDetails Cefpiramide D-alanyl-D-alanine carboxypeptidase DacC Protein Escherichia coli (strain K12) YesInhibitorDetails Cefpiramide Penicillin-binding protein 1A Protein Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) YesInhibitorDetails Cefpiramide Penicillin-binding protein 1A Protein Escherichia coli (strain K12) YesInhibitorDetails Cefpiramide Penicillin-binding protein 1B Protein Escherichia coli (strain K12) YesInhibitorDetails Cefpiramide Penicillin-binding protein 1B Protein Pseudomonas aeruginosa YesInhibitorDetails Cefpiramide Peptidoglycan synthase FtsI Protein Escherichia coli (strain K12) YesInhibitorDetails