Intrinsic novobiocin resistance in Staphylococcus saprophyticus.

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Vickers AA, Chopra I, O'Neill AJ

Intrinsic novobiocin resistance in Staphylococcus saprophyticus.

Antimicrob Agents Chemother. 2007 Dec;51(12):4484-5. Epub 2007 Sep 17.

PubMed ID
17876001 [ View in PubMed
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Abstract

Intrinsic novobiocin resistance in Staphylococcus saprophyticus was associated with expression of a novobiocin-resistant form of the drug target protein (GyrB). Site-directed mutagenesis established that resistance depends upon the presence of two specific amino acid residues in GyrB: a glycine at position 85 and a lysine at position 140.

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