The postsynaptic effects of antidepressant drugs in the rat anococcygeus muscle.

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Doggrell SA, Vincent L

The postsynaptic effects of antidepressant drugs in the rat anococcygeus muscle.

J Pharm Pharmacol. 1981 Nov;33(11):720-4.

PubMed ID
6118411 [ View in PubMed
]
Abstract

The effects of antidepressants of tricyclic (amitriptyline, nortriptyline, protriptyline, doxepin, imipramine, and desipramine) and atypical (maprotiline, nomifensine, tandamine, viloxazine, CGP 6085A, and YM-08054-1) structures on contractile responses to exogenously applied acetylcholine and (-) noradrenaline were studied in rat isolated anococcygeus muscle previously incubated with 6-hydroxydopamine. Atropine, amitriptyline, protriptyline, doxepin, imipramine, maprotiline and nortriptyline inhibited contractile responses to acetylcholine whereas desipramine, nomifensine, tandamine, viloxazine, CGP 6085A and YM 08054-1 did not. The contractile responses to (-)-noradrenaline were inhibited by low concentrations of tricyclic antidepressants and by higher concentrations of the atypical agents. These results illustrate that, in the preparation, the order of potency of antidepressants as muscarinic and as postsynaptic alpha-adrenoceptor antagonists is similar. The ability of tricyclic, but not atypical agents, to increase the concentration of noradrenaline bound to postsynaptic alpha-adrenoceptors may be severely limited by the antagonistic effect these agents have at this receptor.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
MaprotilineMuscarinic acetylcholine receptor M1ProteinHumans
No
Antagonist
Details
MaprotilineMuscarinic acetylcholine receptor M2ProteinHumans
No
Antagonist
Details
MaprotilineMuscarinic acetylcholine receptor M3ProteinHumans
No
Antagonist
Details
MaprotilineMuscarinic acetylcholine receptor M4ProteinHumans
No
Antagonist
Details
MaprotilineMuscarinic acetylcholine receptor M5ProteinHumans
No
Antagonist
Details