Effects of anti-inflammatory biflavonoid, ginkgetin, on chronic skin inflammation.

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Lim H, Son KH, Chang HW, Kang SS, Kim HP

Effects of anti-inflammatory biflavonoid, ginkgetin, on chronic skin inflammation.

Biol Pharm Bull. 2006 May;29(5):1046-9.

PubMed ID

16651744 [ View in PubMed

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Abstract

Ginkgetin, a biflavonoid from Ginkgo biloba leaves (Ginkgoaceae), was previously demonstrated to inhibit phospholipase A2 and to suppress proinflammatory gene expression such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase. In this study, the effects of ginkgetin were examined on an animal model of chronic skin inflammation and proinflammatory gene expression. When topically applied to ICR mouse ear, ginkgetin (20-80 microg/ear/treatment) inhibited ear edema (22.8-30.5%) and prostaglandin E2 production (30.2-31.1%) induced by multiple treatment of 12-O-tetradecanoylphorbol-13-acetate (TPA) for 7 consecutive days. By histological comparison, ginkgetin was also found to reduce epidermal hyperplasia. The expression of proinflammatory gene, interleukin-1beta, was suppressed by ginkgetin. From the results, it is suggested that ginkgetin may be beneficial against chronic skin inflammatory disorders like atopic dermatitis.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Ginkgo biloba	Phospholipase A2, membrane associated	Protein	Humans	Unknown	Inhibitor	Details