Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport.

Article Details

Citation

Sulzer D, Chen TK, Lau YY, Kristensen H, Rayport S, Ewing A

Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport.

J Neurosci. 1995 May;15(5 Pt 2):4102-8.

PubMed ID
7751968 [ View in PubMed
]
Abstract

Whether amphetamine acts principally at the plasma membrane or at synaptic vesicles is controversial. We find that d-amphetamine injection into the Planorbis giant dopamine neuron causes robust dopamine release, demonstrating that specific amphetamine uptake is not required. Arguing for action at vesicles, whole-cell capillary electrophoresis of single Planorbis dopamine neurons shows that amphetamine reduces vesicular dopamine, while amphetamine reduces quantal dopamine release from PC12 cells by > 50% per vesicle. Intracellular injection of dopamine into the Planorbis dopamine neuron produces rapid nomifensine-sensitive release, showing that an increased substrate concentration gradient is sufficient to induce release. These experiments indicate that amphetamine acts at the vesicular level where it redistributes dopamine to the cytosol, promoting reverse transport, and dopamine release.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
AmphetamineSynaptic vesicular amine transporterProteinHumans
Yes
Inhibitor
Details
BenzphetamineSynaptic vesicular amine transporterProteinHumans
Yes
Inducer
Details
DextroamphetamineSynaptic vesicular amine transporterProteinHumans
Yes
Inducer
Details
IsomethepteneSynaptic vesicular amine transporterProteinHumans
Yes
Inhibitor
Details
MetamfetamineSynaptic vesicular amine transporterProteinHumans
Yes
Inhibitor
Details
Drug Transporters
DrugTransporterKindOrganismPharmacological ActionActions
EphedrineSynaptic vesicular amine transporterProteinHumans
Unknown
Inhibitor
Details