Enzymatic studies on the mechanism of action of cefoxitin. Correlation between the affinities of cefoxitin to penicillin-binding proteins and its rates of inhibition of the respective penicillin-sensitive reactions in E. coli.
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Matsuhashi M, Tamaki S
Enzymatic studies on the mechanism of action of cefoxitin. Correlation between the affinities of cefoxitin to penicillin-binding proteins and its rates of inhibition of the respective penicillin-sensitive reactions in E. coli.
J Antibiot (Tokyo). 1978 Dec;31(12):1292-5.
- PubMed ID
- 368000 [ View in PubMed]
- Abstract
The affinities of cefoxitin, a cephamycin antibiotic, to penicillin-binding proteins of Escherichia coli were reexamined using a recently developed method for separating penicillin-binding proteins. The inhibitions by this antibiotic of four measurable penicillin-sensitive enzymatic reactions, the reactions of D-alanine carboxypeptidases IA and IB, cross-bridge formation and concomitant release of D-alanine, were also measured. An approximate correlation was found between the affinities of cefoxitin to the penicillin-binding proteins responsible for these reactions and its rates of inhibition of the respective penicillin-sensitive reactions.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Cefoxitin D-alanyl-D-alanine carboxypeptidase DacA Protein Escherichia coli (strain K12) YesInhibitorDetails Cefoxitin D-alanyl-D-alanine carboxypeptidase DacB Protein Escherichia coli (strain K12) YesInhibitorDetails Cefoxitin D-alanyl-D-alanine carboxypeptidase DacC Protein Escherichia coli (strain K12) YesInhibitorDetails Cefoxitin D-alanyl-D-alanine endopeptidase Protein Escherichia coli (strain K12) YesInhibitorDetails Cefoxitin Penicillin-binding protein 1A Protein Escherichia coli (strain K12) YesInhibitorDetails Cefoxitin Penicillin-binding protein 1B Protein Escherichia coli (strain K12) YesInhibitorDetails Cefoxitin Peptidoglycan synthase FtsI Protein Escherichia coli (strain K12) YesInhibitorDetails