Ceftibuten--in-vitro activity against respiratory pathogens, beta-lactamase stability and mechanism of action.

Article Details

Citation

Wise R, Andrews JM, Ashby JP, Thornber D

Ceftibuten--in-vitro activity against respiratory pathogens, beta-lactamase stability and mechanism of action.

J Antimicrob Chemother. 1990 Aug;26(2):209-13.

PubMed ID
2120175 [ View in PubMed
]
Abstract

The in-vitro activity of ceftibuten against respiratory pathogenic bacteria was studied and compared with that of other oral beta-lactam agents. Ceftibuten displayed high activity against Haemophilus influenzae and Branhamella catarrhalis. There was reduced activity against Streptococcus pneumoniae (MIC90 16 mg/l). The protein binding of ceftibuten was 77% and the primary target site PBP 3. A high degree of stability to beta-lactamase hydrolysis was observed.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
CeftibutenPenicillin-binding protein 1AProteinEscherichia coli (strain K12)
Yes
Inhibitor
Details
CeftibutenPenicillin-binding protein 1BProteinEscherichia coli (strain K12)
Yes
Inhibitor
Details
CeftibutenPenicillin-binding protein 2ProteinEscherichia coli (strain K12)
Yes
Inhibitor
Details
CeftibutenPeptidoglycan synthase FtsIProteinEscherichia coli (strain K12)
Yes
Inhibitor
Details