Ceftibuten--in-vitro activity against respiratory pathogens, beta-lactamase stability and mechanism of action.
Article Details
- CitationCopy to clipboard
Wise R, Andrews JM, Ashby JP, Thornber D
Ceftibuten--in-vitro activity against respiratory pathogens, beta-lactamase stability and mechanism of action.
J Antimicrob Chemother. 1990 Aug;26(2):209-13.
- PubMed ID
- 2120175 [ View in PubMed]
- Abstract
The in-vitro activity of ceftibuten against respiratory pathogenic bacteria was studied and compared with that of other oral beta-lactam agents. Ceftibuten displayed high activity against Haemophilus influenzae and Branhamella catarrhalis. There was reduced activity against Streptococcus pneumoniae (MIC90 16 mg/l). The protein binding of ceftibuten was 77% and the primary target site PBP 3. A high degree of stability to beta-lactamase hydrolysis was observed.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Ceftibuten Penicillin-binding protein 1A Protein Escherichia coli (strain K12) YesInhibitorDetails Ceftibuten Penicillin-binding protein 1B Protein Escherichia coli (strain K12) YesInhibitorDetails Ceftibuten Penicillin-binding protein 2 Protein Escherichia coli (strain K12) YesInhibitorDetails Ceftibuten Peptidoglycan synthase FtsI Protein Escherichia coli (strain K12) YesInhibitorDetails