Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics.
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Duarte JD, Cooper-DeHoff RM
Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics.
Expert Rev Cardiovasc Ther. 2010 Jun;8(6):793-802. doi: 10.1586/erc.10.27.
- PubMed ID
- 20528637 [ View in PubMed]
- Abstract
Thiazide and thiazide-like diuretics are among the most commonly used antihypertensives and have been available for over 50 years. However, the mechanism by which these drugs chronically lower blood pressure is poorly understood. Possible mechanisms include direct endothelial- or vascular smooth muscle-mediated vasodilation and indirect compensation to acute decreases in cardiac output. In addition, thiazides are associated with adverse metabolic effects, particularly hyperglycemia, and the mechanistic underpinnings of these effects are also poorly understood. Thiazide-induced hypokalemia, as well as other theories to explain these metabolic disturbances, including increased visceral adiposity, hyperuricemia, decreased glucose metabolism and pancreatic beta-cell hyperpolarization, may play a role. Understanding genetic variants with differential responses to thiazides could reveal new mechanistic candidates for future research to provide a more complete understanding of the blood pressure and metabolic response to thiazide diuretics.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Indapamide Solute carrier family 12 member 3 Protein Humans YesInhibitorDetails Quinethazone Solute carrier family 12 member 1 Protein Humans YesInhibitorDetails Quinethazone Solute carrier family 12 member 2 Protein Humans YesInhibitorDetails Quinethazone Solute carrier family 12 member 3 Protein Humans YesInhibitorDetails - Drug Carriers
Drug Carrier Kind Organism Pharmacological Action Actions Polythiazide Serum albumin Protein Humans UnknownBinderDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareAcebutololHydrochlorothiazide The therapeutic efficacy of Acebutolol can be increased when used in combination with Hydrochlorothiazide. AcebutololMethyclothiazide The therapeutic efficacy of Acebutolol can be increased when used in combination with Methyclothiazide. AcebutololBendroflumethiazide The therapeutic efficacy of Acebutolol can be increased when used in combination with Bendroflumethiazide. AcebutololHydroflumethiazide The therapeutic efficacy of Acebutolol can be increased when used in combination with Hydroflumethiazide. AcebutololChlorothiazide The therapeutic efficacy of Acebutolol can be increased when used in combination with Chlorothiazide.