[Metabolism, mechanism of action and resistance to cytotoxic nucleoside analogues].

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Jordheim LP, Galmarini CM, Dumontet C

[Metabolism, mechanism of action and resistance to cytotoxic nucleoside analogues].

Bull Cancer. 2005 Mar;92(3):239-48.

PubMed ID

15820918 [ View in PubMed

]

Abstract

Cytotoxic nucleoside analogues are widely used in treatment of patients with hematological malignancies as well as for some solid tumors. Resistance developed against these molecules limit their clinical use. Many studies on cell models and clinical samples have identified cellular mechanisms involved in this phenomenon. Here, we describe the available data concerning the proteins involved in the metabolism and the mechanism of action of nucleoside analogues, as well as the clinical studies showing their implication in the resistance to these drugs.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Fludarabine	Deoxycytidine kinase	Protein	Humans	Yes	Agonist	Details