Privileged structures: a useful concept for the rational design of new lead drug candidates.

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Duarte CD, Barreiro EJ, Fraga CA

Privileged structures: a useful concept for the rational design of new lead drug candidates.

Mini Rev Med Chem. 2007 Nov;7(11):1108-19.

PubMed ID

18045214 [ View in PubMed

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Abstract

Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications. In the present work, we describe some examples and applications of the usefulness of the privileged structure concept for the structural design of new drug candidates, by discussing the eligibility of such motifs, including the identification of the N-acylhydrazone template as privileged structures.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Minaprine	Acetylcholinesterase	Protein	Humans	Yes	Inhibitor	Details
Minaprine	Muscarinic acetylcholine receptor M1	Protein	Humans	Unknown	Agonist	Details