Molecular basis for enhanced activity of posaconazole against Absidia corymbifera and Rhizopus oryzae.

Article Details

Citation

Copy to clipboard

Chau AS, Chen G, McNicholas PM, Mann PA

Molecular basis for enhanced activity of posaconazole against Absidia corymbifera and Rhizopus oryzae.

Antimicrob Agents Chemother. 2006 Nov;50(11):3917-9. Epub 2006 Sep 11.

PubMed ID

16966400 [ View in PubMed

]

Abstract

Posaconazole and itraconazole were more potent inhibitors of ergosterol synthesis, in both intact cells and cell extracts from Absidia corymbifera and Rhizopus oryzae, than voriconazole and fluconazole. Similarly, expression of CYP51 from R. oryzae in Saccharomyces cerevisiae significantly increased resistance to fluconazole and voriconazole but not to posaconazole and itraconazole.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Fluconazole	Cytochrome P450 51	Protein	Yeast	Yes	Inhibitor	Details
Tioconazole	Cytochrome P450 51	Protein	Yeast	Yes	Antagonist	Details