cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein.
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Nishimura H, Kakizaki I, Muta T, Sasaki N, Pu PX, Yamashita T, Nagasawa S
cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein.
FEBS Lett. 1995 Jan 3;357(2):207-11.
- PubMed ID
- 7805892 [ View in PubMed]
- Abstract
PK-120 is a substrate for plasma kallikrein (PK), recently purified from human plasma. Here we have established the cDNA sequence for human PK-120 mRNA. The deduced amino sequence of PK-120 revealed that it consists of 902 amino acid residues with a calculated mass of 116,423 Da. The putative cleavage sites by PK have been proposed, suggesting that PK-120 may be a precursor of a bioactive peptide. Most interestingly, PK-120 showed significant sequence identities to heavy chains (HCs) of the inter-alpha-trypsin inhibitor (ITI) superfamily.