In vitro kinetics of the rat brain succinate dehydrogenase inhibition by hexachlorophene.

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Lokanatha V, Sailaja P, Rajendra W

In vitro kinetics of the rat brain succinate dehydrogenase inhibition by hexachlorophene.

J Biochem Mol Toxicol. 1999;13(6):303-6.

PubMed ID

10487417 [ View in PubMed

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Abstract

Brain succinate dehydrogenase (SDH) activity was inhibited by in vitro hexachlorophene (HCP) with a half inhibitory concentration (IC50) of 0.65 x 10(-3) M. The HCP exerted noncompetitive inhibition at 0.5 mM (IC50) on SDH activity. The brain SDH demands more energy of activation (deltaE) in the presence of HCP. The ionizable groups of SDH such as the sulfhydral group of cysteine and alpha-amino groups of cysteine were not altered qualitatively in the presence of HCP.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Hexachlorophene	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	Protein	Humans	Yes	Inhibitor	Details