Molecular modelling of membrane activity of amphotericin B, a polyene macrolide antifungal antibiotic.

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Baginski M, Sternal K, Czub J, Borowski E

Molecular modelling of membrane activity of amphotericin B, a polyene macrolide antifungal antibiotic.

Acta Biochim Pol. 2005;52(3):655-8. Epub 2005 Aug 5.

PubMed ID

16086075 [ View in PubMed

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Abstract

Amphotericin B (AmB) is a well known polyene macrolide antibiotic used to treat systemic fungal infections. Despite its toxicity AmB is still regarded as a life-saving drug. The lack of adequate knowledge of the AmB mechanism of action is a serious obstacle to efficient development of new less toxic derivatives. Complementary to various experimental approaches, computational chemistry methods were used to study AmB mechanism of action. A programme lasting for a decade, that was run by our group covered studies of: i) molecular properties of AmB and its membrane targets, ii) structure and properties of AmB membrane channels, and iii) interaction of AmB with the membrane.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Amphotericin B	Ergosterol	Small molecule	Candida albicans	Yes	Binder	Details