Novel conjugative plasmid from Escherichia coli of swine origin that coharbors the multiresistance gene cfr and the extended-spectrum-beta-lactamase gene blaCTX-M-14b.
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Zhang WJ, Wang XM, Dai L, Hua X, Dong Z, Schwarz S, Liu S
Novel conjugative plasmid from Escherichia coli of swine origin that coharbors the multiresistance gene cfr and the extended-spectrum-beta-lactamase gene blaCTX-M-14b.
Antimicrob Agents Chemother. 2015 Feb;59(2):1337-40. doi: 10.1128/AAC.04631-14. Epub 2014 Nov 24.
- PubMed ID
- 25421479 [ View in PubMed]
- Abstract
Two porcine Escherichia coli isolates harbored the cfr gene on conjugative plasmids of 38,405 bp (pGXEC6) and 41,646 bp (pGXEC3). In these two plasmids, the cfr gene was located within a 4,612-bp region containing a tnpA-IS26-cfr-IS26-Deltahyp element. Plasmid pGXEC3 was almost identical to pGXEC6 except for a 3,235-bp ISEcp1-blaCTX-M-14b insertion. The colocation of the multiresistance cfr gene with an extended-spectrum-beta-lactamase gene on a conjugative plasmid may support the dissemination of these genes by coselection.