Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum.

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Barthel D, Schlitzer M, Pradel G

Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum.

Antimicrob Agents Chemother. 2008 Feb;52(2):774-7. Epub 2007 Dec 3.

PubMed ID

18056275 [ View in PubMed

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Abstract

Antibacterial agents are used in malaria therapy due to their effect on two prokaryote organelles, the mitochondrion and the apicoplast. We demonstrate here that the ribosome-blocking antibiotics telithromycin and quinupristin-dalfopristin, but not linezolid, inhibit the growth of Plasmodium falciparum. Both drugs induce delayed death in the parasite, suggesting that their effect involves the impairment of apicoplast translation processes.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Quinupristin	23S ribosomal RNA	Nucleotide	Enteric bacteria and other eubacteria	Yes	Inhibitor	Details
Quinupristin	50S ribosomal protein L10	Protein	Shigella flexneri	Yes	Inhibitor	Details
Quinupristin	50S ribosomal protein L22	Protein	Escherichia coli O157:H7	Yes	Inhibitor	Details