Part VII. Macrolides, azalides, ketolides, lincosamides, and streptogramins.

Article Details

Citation

Dang V, Nanda N, Cooper TW, Greenfield RA, Bronze MS

Part VII. Macrolides, azalides, ketolides, lincosamides, and streptogramins.

J Okla State Med Assoc. 2007 Mar;100(3):75-81.

PubMed ID
17432033 [ View in PubMed
]
Abstract

In this article we describe antimicrobials that are grouped by their similar mechanism of action, namely inhibition of protein synthesis at the bacterial 50S ribosomal subunit. Macrolides, azalides, and ketolides are primarily used to treat community acquired respiratory tract infections. A lincosamide antibiotic, clindamycin, is primarily used to treat anaerobic infections. A combination of streptogramins, quinupristin/dalfopristin, is used to treat infections due to multiple drug resistant Gram positive cocci.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Quinupristin23S ribosomal RNANucleotideEnteric bacteria and other eubacteria
Yes
Inhibitor
Details
Quinupristin50S ribosomal protein L10ProteinShigella flexneri
Yes
Inhibitor
Details
Quinupristin50S ribosomal protein L22ProteinEscherichia coli O157:H7
Yes
Inhibitor
Details