Part VII. Macrolides, azalides, ketolides, lincosamides, and streptogramins.
Article Details
- CitationCopy to clipboard
Dang V, Nanda N, Cooper TW, Greenfield RA, Bronze MS
Part VII. Macrolides, azalides, ketolides, lincosamides, and streptogramins.
J Okla State Med Assoc. 2007 Mar;100(3):75-81.
- PubMed ID
- 17432033 [ View in PubMed]
- Abstract
In this article we describe antimicrobials that are grouped by their similar mechanism of action, namely inhibition of protein synthesis at the bacterial 50S ribosomal subunit. Macrolides, azalides, and ketolides are primarily used to treat community acquired respiratory tract infections. A lincosamide antibiotic, clindamycin, is primarily used to treat anaerobic infections. A combination of streptogramins, quinupristin/dalfopristin, is used to treat infections due to multiple drug resistant Gram positive cocci.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Quinupristin 23S ribosomal RNA Nucleotide Enteric bacteria and other eubacteria YesInhibitorDetails Quinupristin 50S ribosomal protein L10 Protein Shigella flexneri YesInhibitorDetails Quinupristin 50S ribosomal protein L22 Protein Escherichia coli O157:H7 YesInhibitorDetails