The potential role of colesevelam in the management of prediabetes and type 2 diabetes mellitus.

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Levy P, Jellinger PS

The potential role of colesevelam in the management of prediabetes and type 2 diabetes mellitus.

Postgrad Med. 2010 May;122(3Suppl):1-8. doi: 10.3810/pgm.2010.05.2168.

PubMed ID

20581432 [ View in PubMed

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Abstract

Successful management of prediabetes and type 2 diabetes mellitus (T2DM) requires a multifaceted, multidisciplinary approach that involves patient education and support, lifestyle modification, and appropriate use of pharmacologic interventions with frequent monitoring and adjustment to ensure that target goals for hyperglycemia, dyslipidemia, and hypertension are achieved and maintained. Studies have shown that the bile acid sequestrant colesevelam HCl reduces hemoglobin A1c and low-density lipoprotein-cholesterol levels in patients with prediabetes and T2DM. This article briefly reviews current treatment guidelines for patients with prediabetes and T2DM and the potential role of colesevelam in the management of prediabetes and T2DM with oral antidiabetes agents.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Colesevelam	Bile acids	Group	Humans	Yes	Binder	Details