Access channel residues Ser315 and Asp137 in Mycobacterium tuberculosis catalase-peroxidase (KatG) control peroxidatic activation of the pro-drug isoniazid.

Article Details

Citation

Zhao X, Hersleth HP, Zhu J, Andersson KK, Magliozzo RS

Access channel residues Ser315 and Asp137 in Mycobacterium tuberculosis catalase-peroxidase (KatG) control peroxidatic activation of the pro-drug isoniazid.

Chem Commun (Camb). 2013 Dec 25;49(99):11650-2. doi: 10.1039/c3cc47022a.

PubMed ID
24185282 [ View in PubMed
]
Abstract

Peroxidatic activation of the anti-tuberculosis pro-drug isoniazid by Mycobacterium tuberculosis catalase-peroxidase (KatG) is regulated by gating residues of a heme access channel. The steric restriction at the bottleneck of this channel is alleviated by replacement of residue Asp137 with Ser, according to crystallographic and kinetic studies.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Catalase-peroxidaseP9WIE5Details