Current status of iron overload and chelation with deferasirox.

Article Details

Citation

Choudhry VP, Naithani R

Current status of iron overload and chelation with deferasirox.

Indian J Pediatr. 2007 Aug;74(8):759-64.

PubMed ID
17785900 [ View in PubMed
]
Abstract

A large number of complications in thalassemia major are due mainly to iron overload. Deferoxamine in iron-overloaded patients has established that chelation therapy, when given at an adequate dose, reduces iron-related complications. Parenteral administration and the daily nuisance of an infusion pump hinder the optimal compliance. Deferiprone is moderately effective oral iron chelator. Arthralgia and cytopenias constitute the main side effects. Deferasirox is a new orally effective iron chelator which has been shown to be non-inferior to deferoxamine in clinical trials. Further clinical trials especially in Indian children will tell if it stands the test of time.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
DeferasiroxIronSmall moleculeHumans
Yes
Chelator
Details